Species

EXPRESS® FP

Protect dairy and beef cattle from reproductive diseases with a modified-live virus vaccine

 

Details

The EXPRESS® FP vaccine family, depending on the formulation, provide extensive protection against the most common reproductive diseases, including infectious bovine rhinotracheitis (IBR), bovine viral diarrhea virus (BVDV), leptospirosis and  Campylobacter fetus (vibrio). 

Features & Benefits

Vaccinate with EXPRESS® FP vaccine to help prevent PI calves and keep BVDV and other reproductive diseases out of your herd. 
  

  • Provides protection against bovine viral diarrhea virus (BVDV), infectious bovine respiratory rhinotracheitis (IBR), leptospirosis and vibrio.
  • Proven to prevent PI calves due to BVDV Type 1b, Type 1a and Type 2a.
  • Contains the Singer strain - proven to induce higher levels of BVDV Type 1a and 1b antibodies3.

  

Dosage & Administration

EXPRESS® FP Vaccine Directions and Dosage:

  • Mix the accompanying bottle of diluent.
  • Rehydrate the vaccine by aseptically adding the diluent to the vaccine vial.
  • Mix the rehydrated vaccine and use immediately.
  • Using aseptic technique, inject 2 mL subcutaneously or intramuscularly.
  • If using the subcutaneous route, inject in front of the shoulder and midway of the neck, away from the suprascapular lymph node.
  • For cows and heifers, using aseptic technique, inject a single 2 mL dose subcutaneously or intramuscularly at or about 4 weeks prior to breeding.
  • If initial vaccination, repeat with any EXPRESS® vaccine containing BRSV MLV in 14 to 28 days.
  • Contact your veterinarian or the manufacturer for information on revaccination frequency.

 

EXPRESS Administration Video

EXPRESS Mixing Video

Resources

Labels

EXPRESS FP 5
EXPRESS FP 5-VL5 HB
EXPRESS FP 10 HB

SDS

EXPRESS FP 5
EXPRESS FP 5-VL5 HB
EXPRESS FP 10 HB
Safety

Always read and follow label directions.

Express BVDV Banner
Express BVDV Banner

Top Reasons to Use EXPRESS FP Vaccines

1) Proven to Prevent PI Calves due to BVDV Type 1B

  • Type 1b is the most prevalent strain of bovine viral diarrhea virus (BVDV) in the United States2,3 BVDV Type 1B Graph
  • Contains the Singer strain — found to induce higher levels of BVDV Types 1a and 1b antibodies3

 

2) Provides 365 Days of Immunity

  • Against persistently infected (PI) calves caused by BVDV Types 1a, 1b and 2 
  • Against abortions caused by infectious bovine rhinotracheitis virus (IBRV) 

 

3) Convenient Combinations for Your Herd

  • Effective against urinary shedding of Lepto hardjo bovis (HB) and/or vibriosis 

 

4) Flexible and Safe

  • Label claim allows flexibility to vaccinate pregnant cows or calves nursing pregnant cows if the cows were vaccinated within the last 12 months with any EXPRESS FP vaccine 

EXPRESS® FP Vaccine Assurance Program

Boehringer Ingelheim is confident in the efficacy and safety of EXPRESS FP vaccines to prevent abortions related to infectious bovine rhinotracheitis virus (IBRV), as well as persistently infected (PI) calves from bovine viral diarrhea virus (BVDV), if used correctly and as part of an overall health management program.

Learn More

How BVDV Is Spread

BVDV graphic series icon 1 depicts a PI Female vertically transmitting to PI Calf.

1. From a Persistently Infected (PI) Dam to the Fetus:

If they’re able to viably gestate, PI dams will always produce PI calves. Many will die before 1 year of age; others typically show no clinical signs. 

BVDV graphic series icon 1 depicts a PI Female vertically transmitting to PI Calf.

1. From a Persistently Infected (PI) Dam to the Fetus:

If they’re able to viably gestate, PI dams will always produce PI calves. Many will die before 1 year of age; others typically show no clinical signs. 

BVDV graphic series icon2 depicting a healthy female vertically transmitting to PI Calf

2. From a Transiently Infected Dam to the Fetus:

Calves that become infected in the uterus can be born PI, spreading the virus for a lifetime. 

BVDV graphic series icon2 depicting a healthy female vertically transmitting to PI Calf

2. From a Transiently Infected Dam to the Fetus:

Calves that become infected in the uterus can be born PI, spreading the virus for a lifetime. 

BVDV graphic series icon3 depicting PI Calf horizontally transmitting virus.

3. From PI or Acutely Infected Cattle to Healthy Cattle:

Infected animals can shed the virus in saliva, nasal and eye discharge, urine, feces, milk and semen. Infection then occurs from nose-to-nose contact or when the virus is ingested or inhaled .

BVDV graphic series icon3 depicting PI Calf horizontally transmitting virus.

3. From PI or Acutely Infected Cattle to Healthy Cattle:

Infected animals can shed the virus in saliva, nasal and eye discharge, urine, feces, milk and semen. Infection then occurs from nose-to-nose contact or when the virus is ingested or inhaled .

BVDV graphic series icon 1 depicts a PI Female vertically transmitting to PI Calf.

1. From a Persistently Infected (PI) Dam to the Fetus:

If they’re able to viably gestate, PI dams will always produce PI calves. Many will die before 1 year of age; others typically show no clinical signs. 

BVDV graphic series icon 1 depicts a PI Female vertically transmitting to PI Calf.

1. From a Persistently Infected (PI) Dam to the Fetus:

If they’re able to viably gestate, PI dams will always produce PI calves. Many will die before 1 year of age; others typically show no clinical signs. 

BVDV graphic series icon2 depicting a healthy female vertically transmitting to PI Calf

2. From a Transiently Infected Dam to the Fetus:

Calves that become infected in the uterus can be born PI, spreading the virus for a lifetime. 

BVDV graphic series icon2 depicting a healthy female vertically transmitting to PI Calf

2. From a Transiently Infected Dam to the Fetus:

Calves that become infected in the uterus can be born PI, spreading the virus for a lifetime. 

BVDV graphic series icon3 depicting PI Calf horizontally transmitting virus.

3. From PI or Acutely Infected Cattle to Healthy Cattle:

Infected animals can shed the virus in saliva, nasal and eye discharge, urine, feces, milk and semen. Infection then occurs from nose-to-nose contact or when the virus is ingested or inhaled .

BVDV graphic series icon3 depicting PI Calf horizontally transmitting virus.

3. From PI or Acutely Infected Cattle to Healthy Cattle:

Infected animals can shed the virus in saliva, nasal and eye discharge, urine, feces, milk and semen. Infection then occurs from nose-to-nose contact or when the virus is ingested or inhaled .

PI Calves. Quietly Spreading The Virus for a Lifetime

A graphic icon depicting BVDV virus spreading to a fetus.

Calves become infected while in the uterus

A graphic icon depicting BVDV virus spreading to a fetus.

Calves become infected while in the uterus

4 cows icon

About 50% of PI calves will be “poor doers” and die before about 1 year of age

4 cows icon

About 50% of PI calves will be “poor doers” and die before about 1 year of age

immune system infographic

The virus suppresses the immune system, making calves more susceptible to other diseases

immune system infographic

The virus suppresses the immune system, making calves more susceptible to other diseases

A graphic icon depicting BVDV virus spreading to a fetus.

Calves become infected while in the uterus

A graphic icon depicting BVDV virus spreading to a fetus.

Calves become infected while in the uterus

4 cows icon

About 50% of PI calves will be “poor doers” and die before about 1 year of age

4 cows icon

About 50% of PI calves will be “poor doers” and die before about 1 year of age

immune system infographic

The virus suppresses the immune system, making calves more susceptible to other diseases

immune system infographic

The virus suppresses the immune system, making calves more susceptible to other diseases

Cow with magnifying glass

Other PI calves often show no signs of disease when they’re born

Cow with magnifying glass

Other PI calves often show no signs of disease when they’re born

3 cows with virus icon graphic

They’ll continue to shed the virus daily, exposing other cattle

3 cows with virus icon graphic

They’ll continue to shed the virus daily, exposing other cattle

70-100 percent icon

of non-vaccinated or immunocompromised cattle become infected when exposed to a PI calf 4,5

70-100 percent icon

of non-vaccinated or immunocompromised cattle become infected when exposed to a PI calf 4,5

Cow with magnifying glass

Other PI calves often show no signs of disease when they’re born

Cow with magnifying glass

Other PI calves often show no signs of disease when they’re born

3 cows with virus icon graphic

They’ll continue to shed the virus daily, exposing other cattle

3 cows with virus icon graphic

They’ll continue to shed the virus daily, exposing other cattle

70-100 percent icon

of non-vaccinated or immunocompromised cattle become infected when exposed to a PI calf 4,5

70-100 percent icon

of non-vaccinated or immunocompromised cattle become infected when exposed to a PI calf 4,5

The Importance of the Singer Strain1:

  • Antibody titers of 128 or greater in dams provide protection against BVDV Type 1b fetal infections.
  • Vaccines with the Singer strain induced a higher proportion of calves with BVDV 1b antibody titers of 128 or higher than the vaccine with the NADL strain.
  • 86% of cattle vaccinated with EXPRESS® FP 10 HB reached BVDV Type 1b titers greater than 128.
Table showing BVDV Type 1b titers. Figure 1. The top set of numbers in the last three columns represents the number of animals with titers in the respective group of <4, 4-64, 128 or greater. The bottom set of numbers in those columns represents the percentage of animals for each set of titers. The EXPRESS FP 10 HB ≧128 cell is highlighted: 51 86°. Bovi-Shield GOLD FP 5’s value is 3 5; Vista 5 SQ is 23 37; CattleMaster GOLD FP 5 is 12 20.

 

References

1 Ridpath JF, Lovell G, Neill JD, et al. Change in predominance of bovine viral diarrhea virus subgenotypes among samples submitted to a diagnostic laboratory over a 20-year time span. J Vet Diagn Invest 2011;23(2):185–193.

2 Data on file, Boehringer Ingelheim and BVDVTracker.com. Data collected November 1, 2018, through November 1, 2020. 

3 Fulton RW, Cook BJ, Payton ME, et al. Immune response to bovine viral diarrhea virus (BVDV) vaccines detecting antibodies due to BVDV subtypes 1a, 1b, 2a and 2c. Vaccine 2020;38(24):4032–4037.

4 Fulton RW, Briggs RE, Ridpath JF, et al. Transmission of bovine viral diarrhea virus 1b to susceptible and vaccinated calves by exposure to persistently infected calves. Can J Vet Res 2005;69(3):161–169. 

5 Fulton RW, Johnson BJ, Briggs RE, et al. Challenge with bovine viral diarrhea virus by exposure to persistently infected calves: protection by vaccination and negative results of antigen testing in non-vaccinated acutely infected calves. Can J Vet Res 2006;70(2):121–127. 

Trademarks

EXPRESS® and the EXPRESS logo® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. All other trademarks are the property of their respective owner. ©2025  Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. 

US-RUM-0048-2025