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Respiratory health

Don’t let bovine respiratory disease go after your cattle. Or your bottom line.

Bovine respiratory disease (BRD) can be frustrating for dairy producers for a number of reasons. The multitude of factors that contribute to the disease can make it difficult to prevent or manage. And BRD can lead to significant economic losses:

  • In nationwide surveys, it’s estimated that 12% to 16% of preweaned calves and 6% to 11% of weaned calves experience BRD1
  • It’s the No. 1 cause of mortality in preweaned and weaned dairy calves, with death losses of 2.3% and 1.5%, respectively2
  • Respiratory problems account for approximately 11.3% of adult dairy cow deaths3


Help protect your investment by working with your veterinarian on a BRD prevention protocol, and stay current on the most recent BRD information.

Bovine respiratory disease (BRD)

What is bovine respiratory disease (BRD)?

  • Any disease of the upper and/or lower respiratory tracts
  • Also known as shipping fever 


Cattle affected

  • Most commonly occurs in preweaned and weaned dairy calves (enzootic calf pneumonia)


Disease development

  • A multifactorial etiology that may include viruses, bacteria, host immunity, environmental stressors, nutrition and more
  • Typically, stress and other factors predispose the animal to infection
  • The lining of the respiratory tract may be damaged by viruses such as:
    • Bovine viral diarrhea virus (BVDV) Types 1a, 1b and 2
    • Infectious bovine rhinotracheitis (IBR) caused by bovine herpesvirus-1 (BHV-1)
    • Bovine respiratory syncytial virus (BRSV)
    • Parainfluenza 3 (Pl3) virus
  • Viral damage opens the door for bacteria to invade the lungs:
    • Mannheimia haemolytica
    • Pasteurella multocida
    • Histophilus somni
    • Mycoplasma bovis
    • Salmonella dublin


Clinical signs

  • Severity of signs can vary, depending on the organism(s) involved, but may include:
    • Labored breathing
    • Nasal discharge
    • Coughing
    • Reduced food and water intake
    • Fever, depression
    • Reluctance to move


Diagnosis

  • Physical examination
  • Culture and antibiotic sensitivity, tissue analysis or advanced diagnostics


Treatment

  • Identify and treat sick calves early for best outcomes
  • Work with your veterinarian to choose the right antibiotic
  • Monitor outcomes and refine protocols with your veterinarian


Prevention

  • Vaccinating the dam to help her produce good-quality colostrum
  • Vaccinating calves to help build immunity

Explore respiratory vaccines

Express Boxes

EXPRESS® Vaccine

Express Boxes

EXPRESS® Vaccine

Triangle Family Products

TRIANGLE® Vaccines

Triangle Family Products

TRIANGLE® Vaccines

Pyramid Family No 4

PYRAMID® Vaccines

Pyramid Family No 4

PYRAMID® Vaccines

Express Boxes

EXPRESS® Vaccine

Express Boxes

EXPRESS® Vaccine

Triangle Family Products

TRIANGLE® Vaccines

Triangle Family Products

TRIANGLE® Vaccines

Pyramid Family No 4

PYRAMID® Vaccines

Pyramid Family No 4

PYRAMID® Vaccines

Pyramid Presponse Products

PYRAMID® + PRESPONSE® SQ Vaccines

Pyramid Presponse Products

PYRAMID® + PRESPONSE® SQ Vaccines

Presponse Product Bottles

PRESPONSE® Vaccines

Presponse Product Bottles

PRESPONSE® Vaccines

Pyramid Presponse Products

PYRAMID® + PRESPONSE® SQ Vaccines

Pyramid Presponse Products

PYRAMID® + PRESPONSE® SQ Vaccines

Presponse Product Bottles

PRESPONSE® Vaccines

Presponse Product Bottles

PRESPONSE® Vaccines

Explore respiratory treatments

Zactran Product Bottles

ZACTRAN® (gamithromycin)

Zactran Product Bottles

ZACTRAN® (gamithromycin)

Polyflex Product

POLYFLEX® (ampicillin for injectable suspension)

Polyflex Product

POLYFLEX® (ampicillin for injectable suspension)

BioMycin Family Product Bottles

BIO-MYCIN® 200 (oxytetracyline injection)

BioMycin Family Product Bottles

BIO-MYCIN® 200 (oxytetracyline injection)

Zactran Product Bottles

ZACTRAN® (gamithromycin)

Zactran Product Bottles

ZACTRAN® (gamithromycin)

Polyflex Product

POLYFLEX® (ampicillin for injectable suspension)

Polyflex Product

POLYFLEX® (ampicillin for injectable suspension)

BioMycin Family Product Bottles

BIO-MYCIN® 200 (oxytetracyline injection)

BioMycin Family Product Bottles

BIO-MYCIN® 200 (oxytetracyline injection)

Important safety information

BIO-MYCIN IMPORTANT SAFETY INFORMATION: When administered to cattle, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure. Discontinue treatment at least 28 days prior to slaughter. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Rapid intravenous administration may result in animal collapse. Product should be administered intravenously slowly over a period of at least 5 minutes. Exceeding labeled dose or more than 10 mL per site may result in antibiotic residues beyond the withdrawal period. Reported adverse reactions may be attributed to anaphylaxis or to cardiovascular collapse of unknown cause. For more information, including full prescribing information, visit https://bit.ly/45mr0Ci or call 888-637-4251.

 

POLYFLEX RESIDUE WARNING: Do not treat cattle for more than 7 days. Milk from treated cows must not be used for food during treatment, and for 48 hours (4 milkings) after the last treatment. Cattle must not be slaughtered for food during treatment, and for 144 hours (6 days) after the last treatment. For more information, including full prescribing information, visit https://bit.ly/3EtN2Ib or call 888-637-4251. 

 

ZACTRAN IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine reproductive performance, pregnancy and lactation have not been determined. Subcutaneous injection may cause a transient local tissue reaction in some cattle that may result in trim loss of edible tissues at slaughter. NOT FOR USE IN HUMANS. KEEP OUT OF REACH OF CHILDREN. For more information, including full prescribing information, visit https://bit.ly/ZactranPI or call 888-637-4251.

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Count on Boehringer Ingelheim for a wide array of products to help keep your dairy cattle in good health and at peak performance.

Guterbock WM. the impact of BRD: the current dairy experience. An Health Res Res 2014;15(2):130–134.
USDA APHIS – Veterinary Services, NAHMS. Dairy heifer raiser, 2011: A study of operations that specialize in raising dairy heifers.
USDA APHIS – Veterinary Services, NAHMS. Highlights of Dairy 2007, Part II: Changes in the U.S. Dairy Cattle Industry, 1991–2007.

 

BIO-MYCIN®, EXPRESS®, the EXPRESS logo®, POLYFLEX®, PRESPONSE®, PYRAMID®, the PYRAMID logo®, TRIANGLE® and the TRIANGLE logo® are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. ZACTRAN®is a registered trademark of Boehringer Ingelheim Animal Health France, used under license. ©2026 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. US-RUM-0071-2025